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Test system for the determination of drug susceptibility or resistance markers in non-small cell lung cancer (NSCLC).

GeneValue™ NSCLC Solution

For research use only

Contains library preparation reagents, pipeline and access to GeneValue™ Somatic Software for data analysis.

All-in-one solution

Library preparation reagents

Pipeline

GeneValue™ Somatic Software

Key Benefits

Two stage library preparation protocol

Simultaneous DNA and RNA analysis

Validated pipeline and the software for data analysis

AMP/ASCO/CAP and ACMG variants annotation

Time to result - 24 hours for 16 samples

Features

Specifications

Analyzed
DNA regions

All coding regions (CDSs) of EGFR, KRAS, TP53, NRAS genes;
20-25 exons ALK;
11, 15 exons BRAF;
16-21 exons ERBB2 (HER2);
2, 8, 10, 14, 21 exons PIK3CA;
hotspots of MET and ROS1genes

Analyzed fusions

Any fusions for oncogenes: NTRK1, NTRK2, NTRK3, ALK, ROS1, RET
Gene partner indication only for partners:AKAP13, IRF2BP2, SQSTM1, TRIM24, ETV6, TPM3, EML4, CD74, KIF5B

Exon skipping detection

MET exon 14 skipping;
ERBB2 exon 16 skipping

Features

Specifications

Number of genes

Detected variants

DNA: SNV, INDEL
RNA: exon skipping, fusions

Limitations

The kit is not intended for detection of CNV, extended STR and homopolymer variants

Analyte

DNA and RNA isolated from formalin-fixed, paraffin-embedded tissues (FFPE)

Target enrichment

Multiplex PCR

DNA sequencing regions length, b.p.

9 135

Recommended number of reads per sample

500 000

Read Length

PE 150 + 150

Biological identifier (BID)*

Included

Time to results

24 hours

Data analysis software

Web-based GeneValue™ Software
DualStream Pipeline
GeneValue™ annotation database

Compatible platforms

MiSeq™, MiSeq Dx™, NextSeq™

GeneValue™ NSCLC Solution set 1 (RUO), 96 reactions

Cat.No. GV-L1-96
Contents: Reagent kit for DNA and RNA library preparation with indexes A1…H12, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution set 1-1 (RUO), 16 reactions

Cat.No. GV-L11-16
Contents: Reagent kit for DNA and RNA library preparation with indexes A1…H2, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution set 1-2 (RUO), 16 reactions

Cat.No. GV-L12-16
Contents: Reagent kit for DNA and RNA library preparation with indexes A3…H4, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution set 1-3 (RUO), 16 reactions

Cat.No. GV-L13-16
Contents: Reagent kit for DNA and RNA library preparation with indexes A5…H6, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution set 1-4 (RUO), 16 reactions

Cat.No. GV-L14-16
Contents: Reagent kit for DNA and RNA library preparation with indexes A7…H8, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution set 1-5 (RUO), 16 reactions

Cat.No. GV-L15-16
Contents: Reagent kit for DNA and RNA library preparation with indexes A9…H10, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution set 1-6 (RUO), 16 reactions

Cat.No. GV-L16-16
Contents: Reagent kit for DNA and RNA library preparation with indexes A11…H12, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution DNA set 1 (RUO), 96 reactions

Cat.No. GV-LD1-96
Contents: Reagent kit for DNA library preparation with indexes A1…H12, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution DNA set 1-1 (RUO), 16 reactions

Cat.No. GV-LD11-16
Contents: Reagent kit for DNA library preparation with indexes A1…H2, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution DNA set 1-2 (RUO), 16 reactions

Cat.No. GV-LD12-16
Contents: Reagent kit for DNA library preparation with indexes A3…H4, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution DNA set 1-3 (RUO), 16 reactions

Cat.No. GV-LD13-16
Contents: Reagent kit for DNA library preparation with indexes A5…H6, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution DNA set 1-4 (RUO), 16 reactions

Cat.No. GV-LD14-16
Contents: Reagent kit for DNA library preparation with indexes A7…H8, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution DNA set 1-5 (RUO), 16 reactions

Cat.No. GV-LD15-16
Contents: Reagent kit for DNA library preparation with indexes A9…H10, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution DNA set 1-6 (RUO), 16 reactions

Cat.No. GV-LD16-16
Contents: Reagent kit for DNA library preparation with indexes A11…H12, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution RNA set 1 (RUO), 96 reactions

Cat.No. GV-LR1-96
Contents: Reagent kit for RNA library preparation with indexes A1…H12, access to
GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution RNA set 1-1 (RUO), 16 reactions

Cat.No. GV-LR11-16
Contents: Reagent kit for RNA library preparation with indexes A1…H2, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution RNA set 1-2 (RUO), 16 reactions

Cat.No. GV-LR12-16
Contents: Reagent kit for RNA library preparation with indexes A3…H4, access to
GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution RNA set 1-3 (RUO), 16 reactions

Cat.No. GV-LR13-16
Contents: Reagent kit for RNA library preparation with indexes A5…H6, access to
GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution RNA set 1-4 (RUO), 16 reactions

Cat.No. GV-LR14-16
Contents: Reagent kit for RNA library preparation with indexes A7…H8, access to GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution RNA set 1-5 (RUO), 16 reactions

Cat.No. GV-LR15-16
Contents: Reagent kit for RNA library preparation with indexes A9…H10, access to
GeneValue™ Somatic Software.

GeneValue™ NSCLC Solution RNA set 1-6 (RUO), 16 reactions

Cat.No. GV-LR16-16RUO
Contents: Reagent kit for RNA library preparation with indexes A11…H12, access to
GeneValue™ Somatic Software.

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